Continuous synthesis of bromoalkyl glycosides by Fischer glycosylation in a microreactor

Abstract In this study, bromoalkyl glycosides were successfully synthesized in microreactor scale by Fischer glycosylation. Yields between 24 and 40% after purification achieved using various acidic catalysts conditions. some experiments, yields 180% higher than with previously known methods could be achieved. This study showed also that reversed-phase flash chromatography is more successful normal-phase for the of glycosides. Furthermore, longer bromoalcohols shown to compatible shorter under these reaction